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Reconstitution of ultrawide DNA origami pores in liposomes for transmembrane transportation of macromolecules
The subsequent articles are merged in Scholar. Their mixed citations are counted only for the main post.
2007, first true-time detection of strand Trade in homologous recombination by RecA; discovery of a minimal persistence duration of finishes of microtubules; and resolved the mechanism of biosensing with carbon nanotubes
2015, discovery that condensin is a remarkably flexible protein composition; and very first detection of DNA knots utilizing nanopores
Illustration (3) of bending configurations in 3D simulations of DNA rods on nanopores. A percentage of the membrane is proven in gray, the rim on the pore is highlighted in red, in addition to a 3D rendering on the motion with the DNA rod is shown.
Length Charge of particular person carbon nanotubes by nanostructuring Along with the scanning tunneling microscope
2000, discovery that nanotubes can carry amazing large recent densities; fixed the controversial problem of electronic transportation as a result of DNA molecules by measurements of insulating behavior at The only molecule stage; and demonstration of the AFM method for solitary-molecule manipulation of nanotubes
In 1993, like a younger and keen affiliate professor at Delft University of Engineering, I'd in the beginning focused the analysis initiatives of my team on measuring the electrical conductance of only one conducting-polymer molecule. Inside two several years, we experienced established a device by which an individual wire of the phthalocyaninepolysiloxane polymer was linked concerning two intently spaced metal nanoelectrodes.
Resolving the stage dimension in condensin-driven DNA loop extrusion identifies ATP binding as the step-generating process
An integrated microfluidic platform for quantifying drug permeation throughout biomimetic vesicle membranes
1999, first ceesdekker.net measurement on the wavefunction of single molecular orbitals of carbon nanotubes; and discovery of kink heterojunctions of carbon nanotubes which gave decisive evidence for your new Luttinger description of interacting electrons in nanotubes
Such as, we think about the nucleopore sophisticated, a gateway in between the mobile nucleus along with the cytoplasm. This is a very complicated procedure and so tough to study inside of a cell, so we use biomimetics. We reconstruct holes and after that insert unique aspects from the nucleopore elaborate to review transportation by means of it at The one-molecule stage.’
It had been an exceptionally fascinating time, for the duration of which I been given lots of assist from Delft College of Technology, in which I used to be a professor at some time, And that i started numerous collaborations with molecular biologists. That aided me master a lot.’